Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method

5-Fluorouracil (5-FU) is an anticancer drug extensively used for different cancers. Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes, DNA and RNA. In this paper, we describ...

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Detalles Bibliográficos
Autores principales: Machon, Christelle, Catez, Frédéric, Venezia, Nicole Dalla, Vanhalle, Floriane, Guyot, Laetitia, Vincent, Anne, Garcia, Maxime, Roy, Béatrice, Diaz, Jean-Jacques, Guitton, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930635/
https://www.ncbi.nlm.nih.gov/pubmed/33717614
http://dx.doi.org/10.1016/j.jpha.2020.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930635/
https://www.ncbi.nlm.nih.gov/pubmed/33717614
http://dx.doi.org/10.1016/j.jpha.2020.04.001

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