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Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method
5-Fluorouracil (5-FU) is an anticancer drug extensively used for different cancers. Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes, DNA and RNA. In this paper, we describ...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Xi'an Jiaotong University
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930635/ https://www.ncbi.nlm.nih.gov/pubmed/33717614 http://dx.doi.org/10.1016/j.jpha.2020.04.001 |