Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled R...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931170/ https://www.ncbi.nlm.nih.gov/pubmed/33686350 http://dx.doi.org/10.1007/s13167-021-00237-2 |
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author | Koklesova, Lenka Samec, Marek Liskova, Alena Zhai, Kevin Büsselberg, Dietrich Giordano, Frank A. Kubatka, Peter Golunitschaja, Olga |
author_facet | Koklesova, Lenka Samec, Marek Liskova, Alena Zhai, Kevin Büsselberg, Dietrich Giordano, Frank A. Kubatka, Peter Golunitschaja, Olga |
author_sort | Koklesova, Lenka |
collection | PubMed |
description | Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled ROS release, diminished energy production and extensive oxidative stress to life-important biomolecules such as mtDNA and chrDNA), individual outcomes differ significantly representing a spectrum of associated pathologies including but not restricted to neurodegeneration, cardiovascular diseases and cancers. Contextually, the role of predictive, preventive and personalised (PPPM/3P) medicine is to introduce predictive analytical approaches which allow for distinguishing between individual outcomes under circumstance of mitochondrial impairments followed by cost-effective targeted prevention and personalisation of medical services. Current article considers innovative concepts and analytical instruments to advance management of mitochondriopathies and associated pathologies. |
format | Online Article Text |
id | pubmed-7931170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-79311702021-03-04 Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine Koklesova, Lenka Samec, Marek Liskova, Alena Zhai, Kevin Büsselberg, Dietrich Giordano, Frank A. Kubatka, Peter Golunitschaja, Olga EPMA J Review Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled ROS release, diminished energy production and extensive oxidative stress to life-important biomolecules such as mtDNA and chrDNA), individual outcomes differ significantly representing a spectrum of associated pathologies including but not restricted to neurodegeneration, cardiovascular diseases and cancers. Contextually, the role of predictive, preventive and personalised (PPPM/3P) medicine is to introduce predictive analytical approaches which allow for distinguishing between individual outcomes under circumstance of mitochondrial impairments followed by cost-effective targeted prevention and personalisation of medical services. Current article considers innovative concepts and analytical instruments to advance management of mitochondriopathies and associated pathologies. Springer International Publishing 2021-03-04 /pmc/articles/PMC7931170/ /pubmed/33686350 http://dx.doi.org/10.1007/s13167-021-00237-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Koklesova, Lenka Samec, Marek Liskova, Alena Zhai, Kevin Büsselberg, Dietrich Giordano, Frank A. Kubatka, Peter Golunitschaja, Olga Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine |
title | Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine |
title_full | Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine |
title_fullStr | Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine |
title_full_unstemmed | Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine |
title_short | Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine |
title_sort | mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3p medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931170/ https://www.ncbi.nlm.nih.gov/pubmed/33686350 http://dx.doi.org/10.1007/s13167-021-00237-2 |
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