Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine

Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled R...

Descripción completa

Detalles Bibliográficos
Autores principales: Koklesova, Lenka, Samec, Marek, Liskova, Alena, Zhai, Kevin, Büsselberg, Dietrich, Giordano, Frank A., Kubatka, Peter, Golunitschaja, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931170/
https://www.ncbi.nlm.nih.gov/pubmed/33686350
http://dx.doi.org/10.1007/s13167-021-00237-2
_version_ 1783660238641037312
author Koklesova, Lenka
Samec, Marek
Liskova, Alena
Zhai, Kevin
Büsselberg, Dietrich
Giordano, Frank A.
Kubatka, Peter
Golunitschaja, Olga
author_facet Koklesova, Lenka
Samec, Marek
Liskova, Alena
Zhai, Kevin
Büsselberg, Dietrich
Giordano, Frank A.
Kubatka, Peter
Golunitschaja, Olga
author_sort Koklesova, Lenka
collection PubMed
description Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled ROS release, diminished energy production and extensive oxidative stress to life-important biomolecules such as mtDNA and chrDNA), individual outcomes differ significantly representing a spectrum of associated pathologies including but not restricted to neurodegeneration, cardiovascular diseases and cancers. Contextually, the role of predictive, preventive and personalised (PPPM/3P) medicine is to introduce predictive analytical approaches which allow for distinguishing between individual outcomes under circumstance of mitochondrial impairments followed by cost-effective targeted prevention and personalisation of medical services. Current article considers innovative concepts and analytical instruments to advance management of mitochondriopathies and associated pathologies.
format Online
Article
Text
id pubmed-7931170
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-79311702021-03-04 Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine Koklesova, Lenka Samec, Marek Liskova, Alena Zhai, Kevin Büsselberg, Dietrich Giordano, Frank A. Kubatka, Peter Golunitschaja, Olga EPMA J Review Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and multi-organ damage frequently developed in a reciprocal manner. Although the origin of the damage is common (uncontrolled ROS release, diminished energy production and extensive oxidative stress to life-important biomolecules such as mtDNA and chrDNA), individual outcomes differ significantly representing a spectrum of associated pathologies including but not restricted to neurodegeneration, cardiovascular diseases and cancers. Contextually, the role of predictive, preventive and personalised (PPPM/3P) medicine is to introduce predictive analytical approaches which allow for distinguishing between individual outcomes under circumstance of mitochondrial impairments followed by cost-effective targeted prevention and personalisation of medical services. Current article considers innovative concepts and analytical instruments to advance management of mitochondriopathies and associated pathologies. Springer International Publishing 2021-03-04 /pmc/articles/PMC7931170/ /pubmed/33686350 http://dx.doi.org/10.1007/s13167-021-00237-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Koklesova, Lenka
Samec, Marek
Liskova, Alena
Zhai, Kevin
Büsselberg, Dietrich
Giordano, Frank A.
Kubatka, Peter
Golunitschaja, Olga
Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
title Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
title_full Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
title_fullStr Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
title_full_unstemmed Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
title_short Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
title_sort mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3p medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931170/
https://www.ncbi.nlm.nih.gov/pubmed/33686350
http://dx.doi.org/10.1007/s13167-021-00237-2
work_keys_str_mv AT koklesovalenka mitochondrialimpairmentsinaetiopathologyofmultifactorialdiseasescommonoriginbutindividualoutcomesincontextof3pmedicine
AT samecmarek mitochondrialimpairmentsinaetiopathologyofmultifactorialdiseasescommonoriginbutindividualoutcomesincontextof3pmedicine
AT liskovaalena mitochondrialimpairmentsinaetiopathologyofmultifactorialdiseasescommonoriginbutindividualoutcomesincontextof3pmedicine
AT zhaikevin mitochondrialimpairmentsinaetiopathologyofmultifactorialdiseasescommonoriginbutindividualoutcomesincontextof3pmedicine
AT busselbergdietrich mitochondrialimpairmentsinaetiopathologyofmultifactorialdiseasescommonoriginbutindividualoutcomesincontextof3pmedicine
AT giordanofranka mitochondrialimpairmentsinaetiopathologyofmultifactorialdiseasescommonoriginbutindividualoutcomesincontextof3pmedicine
AT kubatkapeter mitochondrialimpairmentsinaetiopathologyofmultifactorialdiseasescommonoriginbutindividualoutcomesincontextof3pmedicine
AT golunitschajaolga mitochondrialimpairmentsinaetiopathologyofmultifactorialdiseasescommonoriginbutindividualoutcomesincontextof3pmedicine