Optimization of dose and route of administration of the P‐glycoprotein inhibitor, valspodar (PSC‐833) and the P‐glycoprotein and breast cancer resistance protein dual‐inhibitor, elacridar (GF120918) as dual infusion in rats

Transporters can play a key role in the absorption, distribution, metabolism, and excretion of drugs. Understanding these contributions early in drug discovery allows for more accurate projection of the clinical pharmacokinetics. One method to assess the impact of transporters in vivo involves co‐do...

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Detalles Bibliográficos
Autores principales: Rowbottom, Christopher, Pietrasiewics, Alicia, Tuczewycz, Taras, Grater, Richard, Qiu, Daniel, Kapadnis, Sudarshan, Trapa, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931226/
https://www.ncbi.nlm.nih.gov/pubmed/33660938
http://dx.doi.org/10.1002/prp2.740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931226/
https://www.ncbi.nlm.nih.gov/pubmed/33660938
http://dx.doi.org/10.1002/prp2.740

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