Cargando…

Pentoxifylline Sensitizes Cisplatin-Resistant Human Cervical Cancer Cells to Cisplatin Treatment: Involvement of Mitochondrial and NF-Kappa B Pathways

BACKGROUND: Cervical cancer continues to be a major public health problem worldwide, and Cisplatin is used as first-line chemotherapy for this cancer; however, malignant cells exposed to CISplatin (CIS) become insensitive to the effects of this drug. PenToXifylline (PTX) is a xanthine that sensitize...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bravo-Cuellar, Alejandro, Ortiz-Lazareno, Pablo Cesar, Sierra-Díaz, Erick, Solorzano-Ibarra, Fabiola, Méndez-Clemente, Anibal Samael, Aguilar-Lemarroy, Adriana, Jave-Suárez, Luis Felipe, Ruiz Velazco-Niño, Édgar, Hernández-Flores, Georgina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931705/ https://www.ncbi.nlm.nih.gov/pubmed/33680921 http://dx.doi.org/10.3389/fonc.2020.592706

Ejemplares similares

Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence
por: Hernandez-Flores, Georgina, et al.
Publicado: (2011)

Pentoxifylline Inhibits TNF-α/TGF-β1-Induced Epithelial-Mesenchymal Transition via Suppressing the NF-κB Pathway and SERPINE1 Expression in CaSki Cells
por: Palafox-Mariscal, Luis Arturo, et al.
Publicado: (2023)

Dual STAT-3 and IL-6R inhibition with stattic and tocilizumab decreases migration, invasion and proliferation of prostate cancer cells by targeting the IL-6/IL-6R/STAT-3 axis
por: Méndez-Clemente, Anibal, et al.
Publicado: (2022)

Sensitization of cervix cancer cells to Adriamycin by Pentoxifylline induces an increase in apoptosis and decrease senescence
por: Bravo-Cuellar, Alejandro, et al.
Publicado: (2010)

Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65
por: Bravo-Cuellar, Alejandro, et al.
Publicado: (2013)

Sensitization of U937 leukemia cells to doxorubicin by the MG132 proteasome inhibitor induces an increase in apoptosis by suppressing NF-kappa B and mitochondrial membrane potential loss
por: Ortiz-Lazareno, Pablo César, et al.
Publicado: (2014)

Sensitizing the cytotoxic action of Docetaxel induced by Pentoxifylline in a PC3 prostate cancer cell line
por: Cancino-Marentes, Martha E., et al.
Publicado: (2021)

Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats
por: Fallahzadeh, Ali Reza, et al.
Publicado: (2017)

Restoration of WNT4 inhibits cell growth in leukemia-derived cell lines
por: García-Castro, Beatriz, et al.
Publicado: (2013)

Increase of IFN-γ and TNF-α production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor
por: Gómez-Lomelí, Paulina, et al.
Publicado: (2014)

Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications
por: Jimenez-Perez, Miriam I, et al.
Publicado: (2012)

Cervical Cancer Cell Supernatants Induce a Phenotypic Switch from U937-Derived Macrophage-Activated M1 State into M2-Like Suppressor Phenotype with Change in Toll-Like Receptor Profile
por: Sánchez-Reyes, Karina, et al.
Publicado: (2014)

Comparative Genomic Hybridization and Transcriptome Sequencing Reveal Genes with Gain in Acute Lymphoblastic Leukemia: JUP Expression Emerges as a Survival-Related Gene
por: Zapata-García, Jessica Alejandra, et al.
Publicado: (2022)

Apoptosis induction in Jurkat cells and sCD95 levels in women's sera are related with the risk of developing cervical cancer
por: Aguilar-Lemarroy, Adriana, et al.
Publicado: (2008)

Urine TREM-1 as a marker of urinary tract infection in children
por: Sierra-Diaz, Erick, et al.
Publicado: (2017)

Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB
por: Solomon, Leigh A, et al.
Publicado: (2008)

Thymoquinone attenuates cisplatin-induced hepatotoxicity via nuclear factor kappa- β
por: Al-Malki, Abdulrahman L, et al.
Publicado: (2014)

MEIS1, PREP1, and PBX4 Are Differentially Expressed in Acute Lymphoblastic Leukemia: Association of MEIS1 Expression with Higher Proliferation and Chemotherapy Resistance
por: Rosales-Aviña, Judith A, et al.
Publicado: (2011)

Gold Nanorods with Mesoporous Silica Shell: A Promising Platform for Cisplatin Delivery
por: Quiñones, Jaime, et al.
Publicado: (2023)

MHC class I-related chain A and B ligands are differentially expressed in human cervical cancer cell lines
por: del Toro-Arreola, Susana, et al.
Publicado: (2011)

Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation
por: Ochoa-Hernández, Alejandra B, et al.
Publicado: (2012)

Pilot study: management with pentoxifylline in patients with chronic liver disease and COVID-19
por: Jiménez-Luévano, MA, et al.
Publicado: (2022)

E6/E7 and E6(*) From HPV16 and HPV18 Upregulate IL-6 Expression Independently of p53 in Keratinocytes
por: Artaza-Irigaray, Cristina, et al.
Publicado: (2019)

Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation
por: Bohm, Lothar
Publicado: (2006)

Combination therapy with cisplatin and nifedipine induces apoptosis in cisplatin-sensitive and cisplatin-resistant human glioblastoma cells.
por: Kondo, S., et al.
Publicado: (1995)

PTOV1 promotes cisplatin-induced chemotherapy resistance by activating the nuclear factor kappa B pathway in ovarian cancer
por: Shen, Hongwei, et al.
Publicado: (2021)

Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence
por: Iram, Sana, et al.
Publicado: (2019)

Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor-kappa B (NF-κB) pathway
por: AKTEPE, Oktay Halit, et al.
Publicado: (2021)

Cisplatin-resistant HepG2 cell-derived exosomes transfer cisplatin resistance to cisplatin-sensitive cells in HCC
por: Tang, Zuxiong, et al.
Publicado: (2021)

Active Efflux System for Cisplatin in Cisplatin‐resistant Human KB Cells
por: Fujii, Ryu‐ichi, et al.
Publicado: (1994)

Cisplatin in breast cancer.
por: Willemse, P., et al.
Publicado: (1993)

Tirapazamine-cisplatin: the synergy.
por: Gatzemeier, U., et al.
Publicado: (1998)

Mechanisms of Cisplatin Nephrotoxicity
por: Miller, Ronald P., et al.
Publicado: (2010)

Prevention of cisplatin nephrotoxicity
por: Hayati, Fatemeh, et al.
Publicado: (2015)

Beyond Cisplatin – I
por: Messing, Edward M.
Publicado: (2016)

Preferential Cochleotoxicity of Cisplatin
por: Prayuenyong, Pattarawadee, et al.
Publicado: (2021)

Cisplatin ototoxicity histopathology
por: Hodge, Sarah E., et al.
Publicado: (2021)

Severe acute respiratory syndrome coronavirus 2 ORF3a induces the expression of ACE2 in oral and pulmonary epithelial cells and the food supplement Vita Deyun(®) diminishes this effect
por: Aguilar-Lemarroy, Adriana, et al.
Publicado: (2021)

Mechanism of hyperthermic potentiation of cisplatin action in cisplatin-sensitive and -resistant tumour cells.
por: Hettinga, J. V., et al.
Publicado: (1997)

Nimotuzumab-cisplatin-radiation versus cisplatin-radiation in HPV negative oropharyngeal cancer
por: Noronha, Vanita, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qdfvvbdnnpr3utebrhpsej7d2v