Genome editing to model and reverse a prevalent mutation associated with myeloproliferative neoplasms

Myeloproliferative neoplasms (MPNs) cause the over-production of blood cells such as erythrocytes (polycythemia vera) or platelets (essential thrombocytosis). JAK2 V617F is the most prevalent somatic mutation in many MPNs, but previous modeling of this mutation in mice relied on transgenic overexpre...

Descripción completa

Detalles Bibliográficos
Autores principales: Baik, Ron, Wyman, Stacia K., Kabir, Shaheen, Corn, Jacob E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932127/
https://www.ncbi.nlm.nih.gov/pubmed/33661998
http://dx.doi.org/10.1371/journal.pone.0247858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932127/
https://www.ncbi.nlm.nih.gov/pubmed/33661998
http://dx.doi.org/10.1371/journal.pone.0247858

Ejemplares similares