Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons

Mutations in the presenilin genes (PS1, PS2) have been linked to the majority of familial Alzheimer’s disease (AD). Although great efforts have been made to investigate pathogenic PS mutations, which ultimately cause an increase in the toxic form of β-amyloid (Aβ), the intrinsic physiological functi...

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Detalles Bibliográficos
Autores principales: Watanabe, Hirotaka, Imaizumi, Kent, Cai, Tetsuo, Zhou, Zhi, Tomita, Taisuke, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932187/
https://www.ncbi.nlm.nih.gov/pubmed/33608391
http://dx.doi.org/10.1523/ENEURO.0500-20.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932187/
https://www.ncbi.nlm.nih.gov/pubmed/33608391
http://dx.doi.org/10.1523/ENEURO.0500-20.2021

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