Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta

Molecular chaperon SERPINA3 colocalizes with accumulated amyloid peptide in Alzheimer’s disease (AD) patient’s brain. From the QTL analysis, we narrowed down Serpina3 with two SNPs in senescence-accelerated mouse prone (SAMP) 8 strain. Our study showed SAMP8 type Serpina3 prolonged retention of olig...

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Detalles Bibliográficos
Autores principales: Akbor, Maruf Mohammad, Kurosawa, Nobuyuki, Nakayama, Hiroki, Nakatani, Ayumi, Tomobe, Koji, Chiba, Yoichi, Ueno, Masaki, Tanaka, Masashi, Nomura, Yasuyuki, Isobe, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932536/
https://www.ncbi.nlm.nih.gov/pubmed/33662018
http://dx.doi.org/10.1371/journal.pone.0248027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932536/
https://www.ncbi.nlm.nih.gov/pubmed/33662018
http://dx.doi.org/10.1371/journal.pone.0248027

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