Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish

While zebrafish is emerging as a new model system to study human diseases, an efficient methodology to generate precise point mutations at high efficiency is still lacking. Here we show that base editors can generate C-to-T point mutations with high efficiencies without other unwanted on-target muta...

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Detalles Bibliográficos
Autores principales: Rosello, Marion, Vougny, Juliette, Czarny, François, Mione, Marina C, Concordet, Jean-Paul, Albadri, Shahad, Del Bene, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932688/
https://www.ncbi.nlm.nih.gov/pubmed/33576334
http://dx.doi.org/10.7554/eLife.65552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932688/
https://www.ncbi.nlm.nih.gov/pubmed/33576334
http://dx.doi.org/10.7554/eLife.65552

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