Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability

Neuronal activity-dependent gene expression is essential for brain development. While transcriptional and epigenetic effects of neuronal activity have been explored in the mouse, such an investigation is lacking in human. Because alterations in GABAergic neuronal circuits are implicated in neurologi...

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Detalles Bibliográficos
Autores principales: Boulting, Gabriella L., Durresi, Ershela, Ataman, Bulent, Sherman, Maxwell A., Mei, Kevin, Harmin, David A., Carter, Ava C., Hochbaum, Daniel R., Granger, Adam J., Engreitz, Jesse M, Hrvatin, Sinisa, Blanchard, Michael R., Yang, Marty G., Griffith, Eric C., Greenberg, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933108/
https://www.ncbi.nlm.nih.gov/pubmed/33542524
http://dx.doi.org/10.1038/s41593-020-00786-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933108/
https://www.ncbi.nlm.nih.gov/pubmed/33542524
http://dx.doi.org/10.1038/s41593-020-00786-1

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