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Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability
Neuronal activity-dependent gene expression is essential for brain development. While transcriptional and epigenetic effects of neuronal activity have been explored in the mouse, such an investigation is lacking in human. Because alterations in GABAergic neuronal circuits are implicated in neurologi...
Autores principales: | Boulting, Gabriella L., Durresi, Ershela, Ataman, Bulent, Sherman, Maxwell A., Mei, Kevin, Harmin, David A., Carter, Ava C., Hochbaum, Daniel R., Granger, Adam J., Engreitz, Jesse M, Hrvatin, Sinisa, Blanchard, Michael R., Yang, Marty G., Griffith, Eric C., Greenberg, Michael E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933108/ https://www.ncbi.nlm.nih.gov/pubmed/33542524 http://dx.doi.org/10.1038/s41593-020-00786-1 |
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