Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells

The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) plays a crucial role in angiogenesis at least in part through participating in endocytosis and, thereby, endosomal signaling of several cell surface receptors including VEGF receptor-2 and TGFβ receptor in vascular endothelial cells...

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Detalles Bibliográficos
Autores principales: Shimizu, Shota, Yoshioka, Kazuaki, Aki, Sho, Takuwa, Yoh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933152/
https://www.ncbi.nlm.nih.gov/pubmed/33664344
http://dx.doi.org/10.1038/s41598-021-84548-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933152/
https://www.ncbi.nlm.nih.gov/pubmed/33664344
http://dx.doi.org/10.1038/s41598-021-84548-4

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