Distinct effects of V617F and exon12-mutated JAK2 expressions on erythropoiesis in a human induced pluripotent stem cell (iPSC)-based model

Activating mutations affecting the JAK-STAT signal transduction is the genetic driver of myeloproliferative neoplasms (MPNs) which comprise polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis. The JAK2p.V617F mutation can produce both erythrocytosis in PV and thrombocytosis in E...

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Detalles Bibliográficos
Autores principales: Nilsri, Nungruthai, Jangprasert, Panchalee, Pawinwongchai, Jaturawat, Israsena, Nipan, Rojnuckarin, Ponlapat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933160/
https://www.ncbi.nlm.nih.gov/pubmed/33664283
http://dx.doi.org/10.1038/s41598-021-83895-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933160/
https://www.ncbi.nlm.nih.gov/pubmed/33664283
http://dx.doi.org/10.1038/s41598-021-83895-6

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