Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations of TRPV4 cause distinct, tissue-specific diseases, but the pathogenic mechanisms are unknown. Mutations causing peripheral neuropath...

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Detalles Bibliográficos
Autores principales: McCray, Brett A., Diehl, Erika, Sullivan, Jeremy M., Aisenberg, William H., Zaccor, Nicholas W., Lau, Alexander R., Rich, Dominick J., Goretzki, Benedikt, Hellmich, Ute A., Lloyd, Thomas E., Sumner, Charlotte J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933254/
https://www.ncbi.nlm.nih.gov/pubmed/33664271
http://dx.doi.org/10.1038/s41467-021-21699-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933254/
https://www.ncbi.nlm.nih.gov/pubmed/33664271
http://dx.doi.org/10.1038/s41467-021-21699-y

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