Cargando…

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

TRPV4 is a cell surface-expressed calcium-permeable cation channel that mediates cell-specific effects on cellular morphology and function. Dominant missense mutations of TRPV4 cause distinct, tissue-specific diseases, but the pathogenic mechanisms are unknown. Mutations causing peripheral neuropath...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCray, Brett A., Diehl, Erika, Sullivan, Jeremy M., Aisenberg, William H., Zaccor, Nicholas W., Lau, Alexander R., Rich, Dominick J., Goretzki, Benedikt, Hellmich, Ute A., Lloyd, Thomas E., Sumner, Charlotte J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933254/ https://www.ncbi.nlm.nih.gov/pubmed/33664271 http://dx.doi.org/10.1038/s41467-021-21699-y

Ejemplares similares

TRPV4: A trigger of pathological RhoA activation in neurological disease
por: Bagnell, Anna M., et al.
Publicado: (2022)

TRPV4 mutations causing mixed neuropathy and skeletal phenotypes result in severe gain of function
por: Taga, Arens, et al.
Publicado: (2022)

Multiubiquitination of TRPV4 reduces channel activity independent of surface localization
por: Aisenberg, William H., et al.
Publicado: (2022)

TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease
por: Kwon, Do Hoon, et al.
Publicado: (2023)

Structure of human TRPV4 in complex with GTPase RhoA
por: Nadezhdin, Kirill D., et al.
Publicado: (2023)

Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity
por: Goretzki, Benedikt, et al.
Publicado: (2023)

Extent of intrinsic disorder and NMR chemical shift assignments of the distal N-termini from human TRPV1, TRPV2 and TRPV3 ion channels
por: Wiedemann, Christoph, et al.
Publicado: (2022)

Backbone NMR assignments of the extensive human and chicken TRPV4 N-terminal intrinsically disordered regions as important players in ion channel regulation
por: Goretzki, Benedikt, et al.
Publicado: (2022)

Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy
por: Sullivan, Jeremy M., et al.
Publicado: (2015)

Phenotypic variability of TRPV4 related neuropathies
por: Evangelista, Teresinha, et al.
Publicado: (2015)

Calcium and TRPV4 promote metastasis by regulating cytoskeleton through the RhoA/ROCK1 pathway in endometrial cancer
por: Li, Xingchen, et al.
Publicado: (2020)

TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis
por: Toledo Mauriño, Joel J., et al.
Publicado: (2020)

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca(2+)
por: Woolums, Brian M., et al.
Publicado: (2020)

Physiological and Pathological Role of TRPV1, TRPV2 and TRPV4 Channels in Heart
por: Gorbunov, Alexandr S., et al.
Publicado: (2019)

TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway
por: Thoppil, Roslin J., et al.
Publicado: (2016)

Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
por: Facer, Paul, et al.
Publicado: (2007)

TRPV4 in the battle of the sexes
por: Sedwick, Caitlin
Publicado: (2017)

TRPV4 Mechanotransduction in Fibrosis
por: Adapala, Ravi K., et al.
Publicado: (2021)

The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels
por: Baratchi, Sara, et al.
Publicado: (2019)

Ion Transport Regulation by TRPV4 and TRPV1 in Lens and Ciliary Epithelium
por: Delamere, Nicholas A., et al.
Publicado: (2022)

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model
por: Maqboul, Ahmad, et al.
Publicado: (2018)

TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation
por: Huang, Susan M, et al.
Publicado: (2011)

TRPV1 and TRPV4 Play Pivotal Roles in Delayed Onset Muscle Soreness
por: Ota, Hiroki, et al.
Publicado: (2013)

Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens
por: Delamere, Nicholas A., et al.
Publicado: (2020)

Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics
por: Doñate-Macián, Pau, et al.
Publicado: (2019)

Cinnamaldehyde elicits itch behavior via TRPV1 and TRPV4 but not TRPA1
por: Domocos, Dan, et al.
Publicado: (2020)

The Flavonoid Isoquercitrin Promotes Neurite Elongation by Reducing RhoA Activity
por: Palazzolo, Gemma, et al.
Publicado: (2012)

Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA
por: Di Donato, Marzia, et al.
Publicado: (2023)

Modification of TRPV4 activity by acetaminophen
por: Nakagawa, Fumio, et al.
Publicado: (2020)

TRPV4 mediates afferent pathways in the urinary bladder. A spinal c-fos study showing TRPV1 related adaptations in the TRPV4 knockout mouse
por: Janssen, Dick A. W., et al.
Publicado: (2016)

Functional TRPV2 and TRPV4 channels in human cardiac c‐kit(+) progenitor cells
por: Che, Hui, et al.
Publicado: (2016)

Mechanism for Regulation of Melanoma Cell Death via Activation of Thermo-TRPV4 and TRPV2
por: Zheng, Jiaojiao, et al.
Publicado: (2019)

Comparative Analysis of Single-Molecule Dynamics of TRPV1 and TRPV4 Channels in Living Cells
por: Kuwashima, Yutaro, et al.
Publicado: (2021)

ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA
por: Sun, Ying, et al.
Publicado: (2012)

Correction: The Flavonoid Isoquercitrin Promotes Neurite Elongation by Reducing RhoA Activity
por: Palazzolo, Gemma, et al.
Publicado: (2012)

Calsenilin, a Presenilin Interactor, Regulates RhoA Signaling and Neurite Outgrowth
por: Kim, Hee-Jun, et al.
Publicado: (2018)

Increased capsaicin receptor TRPV1 in skin nerve fibres and related vanilloid receptors TRPV3 and TRPV4 in keratinocytes in human breast pain
por: Gopinath, Preethi, et al.
Publicado: (2005)

Attenuation of TRPV1 and TRPV4 Expression and Function in Mouse Inflammatory Pain Models Using Electroacupuncture
por: Chen, Wei-Hsin, et al.
Publicado: (2012)

TRPV4 shows TRPP2 the moves
por: Robinson, Richard
Publicado: (2008)

Activation of TRPV4 promotes osteoclasts differentiation
por: Masuyama, Ritsuko
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8qf6qqrco045il999a9o15eop5