Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis

Treatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4(+) T cells (T(...

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Detalles Bibliográficos
Autores principales: Hutchinson, James A., Kronenberg, Katharina, Riquelme, Paloma, Wenzel, Jürgen J., Glehr, Gunther, Schilling, Hannah-Lou, Zeman, Florian, Evert, Katja, Schmiedel, Martin, Mickler, Marion, Drexler, Konstantin, Bitterer, Florian, Cordero, Laura, Beyer, Lukas, Bach, Christian, Koestler, Josef, Burkhardt, Ralph, Schlitt, Hans J., Hellwig, Dirk, Werner, Jens M., Spang, Rainer, Schmidt, Barbara, Geissler, Edward K., Haferkamp, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933278/
https://www.ncbi.nlm.nih.gov/pubmed/33664251
http://dx.doi.org/10.1038/s41467-021-21572-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933278/
https://www.ncbi.nlm.nih.gov/pubmed/33664251
http://dx.doi.org/10.1038/s41467-021-21572-y

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