Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides

The structural complexity and bioactivity of natural products often depend on enzymatic redox tailoring steps. This is exemplified by the generation of the bisbenzannulated [5,6]-spiroketal pharmacophore in the bacterial rubromycin family of aromatic polyketides, which exhibit a wide array of bioact...

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Detalles Bibliográficos
Autores principales: Frensch, Britta, Lechtenberg, Thorsten, Kather, Michel, Yunt, Zeynep, Betschart, Martin, Kammerer, Bernd, Lüdeke, Steffen, Müller, Michael, Piel, Jörn, Teufel, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933358/
https://www.ncbi.nlm.nih.gov/pubmed/33664266
http://dx.doi.org/10.1038/s41467-021-21432-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933358/
https://www.ncbi.nlm.nih.gov/pubmed/33664266
http://dx.doi.org/10.1038/s41467-021-21432-9

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