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MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1/FAK/Akt signaling

PNO1 has been reported to be involved in tumorigenesis, however, its role in glioma remains unexplored. In the present study, PNO1 expression in glioma from on-line databases, cDNA, and tissue microarrays was upregulated and associated with poor prognosis. PNO1 knockdown inhibits tumor cell growth a...

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Detalles Bibliográficos
Autores principales: Chen, Xu, Guo, Zheng-Qian, Cao, Dan, Chen, Yong, Chen, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933405/
https://www.ncbi.nlm.nih.gov/pubmed/33664245
http://dx.doi.org/10.1038/s41419-021-03532-y