Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity

Irinotecan inhibits cell proliferation and thus is used for the primary treatment of colorectal cancer. Metabolism of irinotecan involves incorporation of β-glucuronic acid to facilitate excretion. During transit of the glucuronidated product through the gastrointestinal tract, an induced upregulati...

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Detalles Bibliográficos
Autores principales: Lin, Hsien-Ya, Chen, Chia-Yu, Lin, Ting-Chien, Yeh, Lun-Fu, Hsieh, Wei-Che, Gao, Shijay, Burnouf, Pierre-Alain, Chen, Bing-Mae, Hsieh, Tung-Ju, Dashnyam, Punsaldulam, Kuo, Yen-Hsi, Tu, Zhijay, Roffler, Steve R., Lin, Chun-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933434/
https://www.ncbi.nlm.nih.gov/pubmed/33664385
http://dx.doi.org/10.1038/s42003-021-01815-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933434/
https://www.ncbi.nlm.nih.gov/pubmed/33664385
http://dx.doi.org/10.1038/s42003-021-01815-w

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