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Immunodominant antibody germlines in COVID-19

The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect aga...

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Bibliographic Details
Main Authors: Andreano, Emanuele, Rappuoli, Rino
Format: Online Article Text
Language:English
Published: Rockefeller University Press 2021
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933983/
https://www.ncbi.nlm.nih.gov/pubmed/33656515
http://dx.doi.org/10.1084/jem.20210281