Immunodominant antibody germlines in COVID-19

The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect aga...

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Detalles Bibliográficos
Autores principales: Andreano, Emanuele, Rappuoli, Rino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933983/
https://www.ncbi.nlm.nih.gov/pubmed/33656515
http://dx.doi.org/10.1084/jem.20210281
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author Andreano, Emanuele
Rappuoli, Rino
author_facet Andreano, Emanuele
Rappuoli, Rino
author_sort Andreano, Emanuele
collection PubMed
description The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect against emerging SARS-CoV-2 variants?
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spelling pubmed-79339832021-03-10 Immunodominant antibody germlines in COVID-19 Andreano, Emanuele Rappuoli, Rino J Exp Med Viewpoint The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect against emerging SARS-CoV-2 variants? Rockefeller University Press 2021-03-03 /pmc/articles/PMC7933983/ /pubmed/33656515 http://dx.doi.org/10.1084/jem.20210281 Text en © 2021 Andreano and Rappuoli http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Viewpoint
Andreano, Emanuele
Rappuoli, Rino
Immunodominant antibody germlines in COVID-19
title Immunodominant antibody germlines in COVID-19
title_full Immunodominant antibody germlines in COVID-19
title_fullStr Immunodominant antibody germlines in COVID-19
title_full_unstemmed Immunodominant antibody germlines in COVID-19
title_short Immunodominant antibody germlines in COVID-19
title_sort immunodominant antibody germlines in covid-19
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933983/
https://www.ncbi.nlm.nih.gov/pubmed/33656515
http://dx.doi.org/10.1084/jem.20210281
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