Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

The ability to monitor anti-tumor CD8(+) T cell responses in the blood has tremendous therapeutic potential. Here, we used paired single-cell RNA and TCR sequencing to detect and characterize “tumor-matching” (TM) CD8(+) T cells in the blood of mice with MC38 tumors or melanoma patients using the TC...

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Detalles Bibliográficos
Autores principales: Pauken, Kristen E., Shahid, Osmaan, Lagattuta, Kaitlyn A., Mahuron, Kelly M., Luber, Jacob M., Lowe, Margaret M., Huang, Linglin, Delaney, Conor, Long, Jaclyn M., Fung, Megan E., Newcomer, Kathleen, Tsai, Katy K., Chow, Melissa, Guinn, Samantha, Kuchroo, Juhi R., Burke, Kelly P., Schenkel, Jason M., Rosenblum, Michael D., Daud, Adil I., Sharpe, Arlene H., Singer, Meromit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933992/
https://www.ncbi.nlm.nih.gov/pubmed/33651880
http://dx.doi.org/10.1084/jem.20200920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933992/
https://www.ncbi.nlm.nih.gov/pubmed/33651880
http://dx.doi.org/10.1084/jem.20200920

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