Cargando…

Edible CaCO(3) nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation

BACKGROUND: Nanoparticles assembled from food-grade calcium carbonate have attracted attention because of their biocompatibility, digestibility, particle and surface features (such as size, surface area, and partial wettability), and stimuli-responsiveness offered by their acid-labile nature. RESULT...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Xiaoming, Li, Xiaoying, Chan, Leung, Huang, Wei, Chen, Tianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934247/
https://www.ncbi.nlm.nih.gov/pubmed/33663532
http://dx.doi.org/10.1186/s12951-021-00807-6
_version_ 1783660783892168704
author Guo, Xiaoming
Li, Xiaoying
Chan, Leung
Huang, Wei
Chen, Tianfeng
author_facet Guo, Xiaoming
Li, Xiaoying
Chan, Leung
Huang, Wei
Chen, Tianfeng
author_sort Guo, Xiaoming
collection PubMed
description BACKGROUND: Nanoparticles assembled from food-grade calcium carbonate have attracted attention because of their biocompatibility, digestibility, particle and surface features (such as size, surface area, and partial wettability), and stimuli-responsiveness offered by their acid-labile nature. RESULTS: Herein, a type of edible oil-in-water Pickering emulsion was structured by calcium carbonate nanoparticles (CaCO(3) NPs; mean particle size: 80 nm) and medium-chain triglyceride (MCT) for delivery of lipophilic drugs and simultaneous oral supplementation of calcium. The microstructure of the as-made CaCO(3) NPs stabilized Pickering emulsion can be controlled by varying the particle concentration (c) and oil volume fraction (φ). The emulsification stabilizing capability of the CaCO(3) NPs also favored the formation of high internal phase emulsion at a high φ of 0.7–0.8 with excellent emulsion stability at room temperature and at 4 °C, thus protecting the encapsulated lipophilic bioactive, vitamin D3 (VD3), against degradation. Interestingly, the structured CaCO(3) NP-based Pickering emulsion displayed acid-trigged demulsification because of the disintegration of the CaCO(3) NPs into Ca(2+) in a simulated gastric environment, followed by efficient lipolysis of the lipid in simulated intestinal fluid. With the encapsulation and delivery of the emulsion, VD3 exhibited satisfying bioavailability after simulated gastrointestinal digestion. CONCLUSIONS: Taken together, the rationally designed CaCO(3) NP emulsion system holds potential as a calcium-fortified formulation for food, pharmaceutical and biomedical applications. [Image: see text]
format Online
Article
Text
id pubmed-7934247
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-79342472021-03-05 Edible CaCO(3) nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation Guo, Xiaoming Li, Xiaoying Chan, Leung Huang, Wei Chen, Tianfeng J Nanobiotechnology Research BACKGROUND: Nanoparticles assembled from food-grade calcium carbonate have attracted attention because of their biocompatibility, digestibility, particle and surface features (such as size, surface area, and partial wettability), and stimuli-responsiveness offered by their acid-labile nature. RESULTS: Herein, a type of edible oil-in-water Pickering emulsion was structured by calcium carbonate nanoparticles (CaCO(3) NPs; mean particle size: 80 nm) and medium-chain triglyceride (MCT) for delivery of lipophilic drugs and simultaneous oral supplementation of calcium. The microstructure of the as-made CaCO(3) NPs stabilized Pickering emulsion can be controlled by varying the particle concentration (c) and oil volume fraction (φ). The emulsification stabilizing capability of the CaCO(3) NPs also favored the formation of high internal phase emulsion at a high φ of 0.7–0.8 with excellent emulsion stability at room temperature and at 4 °C, thus protecting the encapsulated lipophilic bioactive, vitamin D3 (VD3), against degradation. Interestingly, the structured CaCO(3) NP-based Pickering emulsion displayed acid-trigged demulsification because of the disintegration of the CaCO(3) NPs into Ca(2+) in a simulated gastric environment, followed by efficient lipolysis of the lipid in simulated intestinal fluid. With the encapsulation and delivery of the emulsion, VD3 exhibited satisfying bioavailability after simulated gastrointestinal digestion. CONCLUSIONS: Taken together, the rationally designed CaCO(3) NP emulsion system holds potential as a calcium-fortified formulation for food, pharmaceutical and biomedical applications. [Image: see text] BioMed Central 2021-03-04 /pmc/articles/PMC7934247/ /pubmed/33663532 http://dx.doi.org/10.1186/s12951-021-00807-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Guo, Xiaoming
Li, Xiaoying
Chan, Leung
Huang, Wei
Chen, Tianfeng
Edible CaCO(3) nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation
title Edible CaCO(3) nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation
title_full Edible CaCO(3) nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation
title_fullStr Edible CaCO(3) nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation
title_full_unstemmed Edible CaCO(3) nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation
title_short Edible CaCO(3) nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation
title_sort edible caco(3) nanoparticles stabilized pickering emulsion as calcium‐fortified formulation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934247/
https://www.ncbi.nlm.nih.gov/pubmed/33663532
http://dx.doi.org/10.1186/s12951-021-00807-6
work_keys_str_mv AT guoxiaoming ediblecaco3nanoparticlesstabilizedpickeringemulsionascalciumfortifiedformulation
AT lixiaoying ediblecaco3nanoparticlesstabilizedpickeringemulsionascalciumfortifiedformulation
AT chanleung ediblecaco3nanoparticlesstabilizedpickeringemulsionascalciumfortifiedformulation
AT huangwei ediblecaco3nanoparticlesstabilizedpickeringemulsionascalciumfortifiedformulation
AT chentianfeng ediblecaco3nanoparticlesstabilizedpickeringemulsionascalciumfortifiedformulation