Cargando…

Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis

BACKGROUND: The epigenetic abnormality of tumor-associated genes contributes to the pathogenesis of colorectal carcinoma (CRC). However, methylation in colorectal cancer is still poorly characterized. METHOD: By integration of DNA methylation data from the GEO database and gene expression data from...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hui, Xu, Chenxin, Shi, Chen, Zhang, Junying, Qian, Ting, Wang, Zhuo, Ma, Rong, Wu, Jianzhong, Jiang, Feng, Feng, Jifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934273/ https://www.ncbi.nlm.nih.gov/pubmed/33663522 http://dx.doi.org/10.1186/s12967-021-02770-0

Ejemplares similares

Allele Loss and Down-Regulation of Heparanase Gene Are Associated with the Progression and Poor Prognosis of Hepatocellular Carcinoma
por: Huang, Guo-Liang, et al.
Publicado: (2012)

MAPT promoter CpG island hypermethylation is associated with poor prognosis in patients with stage II colorectal cancer
por: Wang, Chuntao, et al.
Publicado: (2019)

MicroRNAs as biomarkers for the progression and prognosis of colon carcinoma
por: Zhang, Hui, et al.
Publicado: (2018)

Promoter hypermethylation of LGALS4 correlates with poor prognosis in patients with urothelial carcinoma
por: Wu, Meei-Maan, et al.
Publicado: (2017)

Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma
por: Gao, Yali, et al.
Publicado: (2017)

CLASRP oncogene as a novel target for colorectal cancer
por: Gu, Quan, et al.
Publicado: (2023)

A Three-Genes Signature Predicting Colorectal Cancer Relapse Reveals LEMD1 Promoting CRC Cells Migration by RhoA/ROCK1 Signaling Pathway
por: Zhang, Hui, et al.
Publicado: (2022)

Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer
por: Hu, Yu-Han, et al.
Publicado: (2017)

The somatic mutation landscape of Chinese Colorectal Cancer
por: Ma, Rong, et al.
Publicado: (2020)

Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression
por: Hu, Yu-Han, et al.
Publicado: (2019)

Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancer
por: Zhang, Jun, et al.
Publicado: (2017)

LINC00460 Hypomethylation Promotes Metastasis in Colorectal Carcinoma
por: Zhang, Hui, et al.
Publicado: (2019)

Promoter Hypermethylation of CHODL Contributes to Carcinogenesis and Indicates Poor Survival in Patients with Early-stage Colorectal Cancer
por: Zhang, Xinyue, et al.
Publicado: (2020)

Role of heparanase in pulmonary hypertension
por: Wang, Lin-Jun, et al.
Publicado: (2023)

The Silencing of RECK Gene is Associated with Promoter Hypermethylation and Poor Survival in Hepatocellular Carcinoma
por: Zhang, Changsong, et al.
Publicado: (2012)

Long noncoding RNAs predict the survival of patients with colorectal cancer as revealed by constructing an endogenous RNA network using bioinformation analysis
por: Zhang, Hui, et al.
Publicado: (2019)

Promoter Hypermethylation-Related Reduced Somatostatin Production Promotes Uncontrolled Cell Proliferation in Colorectal Cancer
por: Leiszter, Katalin, et al.
Publicado: (2015)

Hypermethylation of secreted frizzled-related proteins predicts poor prognosis in non-M3 acute myeloid leukemia
por: Guo, Hong, et al.
Publicado: (2017)

CRNDE mediated hnRNPA2B1 stability facilitates nuclear export and translation of KRAS in colorectal cancer
por: Lu, Ya, et al.
Publicado: (2023)

VLX1570 regulates the proliferation and apoptosis of human lung cancer cells through modulating ER stress and the AKT pathway
por: Wang, Juan, et al.
Publicado: (2021)

Association of DSC3 mRNA Down-Regulation in Prostate Cancer with Promoter Hypermethylation and Poor Prognosis
por: Pan, Jincheng, et al.
Publicado: (2014)

Hypermethylation of BEND5 contributes to cell proliferation and is a prognostic marker of colorectal cancer
por: Lin, Ruo-Kai, et al.
Publicado: (2017)

Overexpression of SYF2 promotes cell proliferation and correlates with poor prognosis in human breast cancer
por: Shi, Feng, et al.
Publicado: (2017)

Elevated heparanase expression is associated with poor prognosis in breast cancer: a study based on systematic review and TCGA data
por: Sun, Xu, et al.
Publicado: (2017)

Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis
por: Hao, Xuewei, et al.
Publicado: (2022)

Promoter hypermethylation of CD133/PROM1 is an independent poor prognosis factor for head and neck squamous cell carcinoma
por: Hu, Zele, et al.
Publicado: (2020)

CDCA4 suppresses epithelial–mesenchymal transtion (EMT) and metastasis in Non-small cell lung cancer through modulating autophagy
por: Xu, Chenxin, et al.
Publicado: (2021)

Hypermethylation of tumor suppressor genes is a risk factor for poor prognosis in ovarian cancer: A meta-analysis
por: Feng, Li-yuan, et al.
Publicado: (2019)

CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer
por: Martín-Sánchez, Esperanza, et al.
Publicado: (2017)

Heparanase is a novel biomarker for immune infiltration and prognosis in breast cancer
por: Yang, Wen-Jing, et al.
Publicado: (2021)

Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation
por: Zhang, Xiaoni, et al.
Publicado: (2020)

Role of heparanase in sepsis‑related acute kidney injury (Review)
por: Li, Jian-Chun, et al.
Publicado: (2023)

Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis
por: Li, Yifan, et al.
Publicado: (2018)

Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer
por: Chen, Cheng, et al.
Publicado: (2013)

TACC3 promotes colorectal cancer tumourigenesis and correlates with poor prognosis
por: Du, Yong, et al.
Publicado: (2016)

UBN2 promotes tumor progression via the Ras/MAPK pathway and predicts poor prognosis in colorectal cancer
por: Zhao, Ya-li, et al.
Publicado: (2019)

Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients
por: Chou, Jian-Liang, et al.
Publicado: (2015)

Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis
por: Tang, Li, et al.
Publicado: (2021)

Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis
por: Liu, Xue, et al.
Publicado: (2019)

Calponin 3 is associated with poor prognosis and regulates proliferation and metastasis in osteosarcoma
por: Dai, Fei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_b9u7aphv9lbpt0osg4flffj6l1