Cargando…

Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension

OBJECTIVES: Pulmonary hypertension (PH) is a life-threatening progressive disease with high mortality in the elderly. However, the pathogenesis of PH has not been fully understood and there is no effective therapy to reverse the disease process. This study aims to determine whether cellular senescen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Kai, Li, Yan, Yu, Youjia, Ding, Jingjing, Huang, Huijie, Chu, Chunyan, Hu, Li, Yu, Yanfang, Cao, Yue, Xu, Peng, Fulton, David, Chen, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934412/ https://www.ncbi.nlm.nih.gov/pubmed/33673825 http://dx.doi.org/10.1186/s12890-021-01439-0

Ejemplares similares

Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery
por: Zhang, Song, et al.
Publicado: (2020)

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
por: Wu, Yuhao, et al.
Publicado: (2022)

Lipopolysaccharide promotes lipid accumulation in human adventitial fibroblasts via TLR4-NF-κB pathway
por: Wang, Jun, et al.
Publicado: (2012)

Urotensin II promotes aldosterone expression in rat aortic adventitial fibroblasts
por: Li, Jun, et al.
Publicado: (2018)

Expression and Function of Osteopontin in Vascular Adventitial Fibroblasts and Pathological Vascular Remodeling
por: Jin, Xin, et al.
Publicado: (2011)

Hydrogen Sulfide Diminishes Activation of Adventitial Fibroblasts Through the Inhibition of Mitochondrial Fission
por: Lu, Zhao-Yang, et al.
Publicado: (2022)

Identification of Serum-Based Metabolic Feature and Characteristic Metabolites in Paraquat Intoxicated Mouse Models
por: Yu, Youjia, et al.
Publicado: (2020)

Adventitial Fibroblast Abormality in Thoracic Aortic Aneurysms and Aortic Dissections
por: Suh, Jong Hui, et al.
Publicado: (2011)

Genome-wide association study identifies loci and candidate genes for non-idiopathic pulmonary hypertension in Eastern Chinese Han population
por: Yin, Caiyong, et al.
Publicado: (2018)

Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts
por: Nawa, Nobutoshi, et al.
Publicado: (2019)

Selective Elimination of Senescent Fibroblasts by Targeting the Cell Surface Protein ACKR3
por: Takaya, Kento, et al.
Publicado: (2022)

Vascular wall microenvironment: exosomes secreted by adventitial fibroblasts induced vascular calcification
por: Zheng, Ming-Hui, et al.
Publicado: (2023)

Nitidine Chloride Alleviates Inflammation and Cellular Senescence in Murine Osteoarthritis Through Scavenging ROS
por: Lin, Changjian, et al.
Publicado: (2022)

Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
por: Chen, Haitao, et al.
Publicado: (2023)

Nutrient Inputs Alleviate Negative Effects of Early and Subsequent Flooding on Growth of Polygonum hydropiper With the Aid of Adventitious Roots
por: Chen, Yu-Han, et al.
Publicado: (2022)

WWOX Modulates ROS-Dependent Senescence in Bladder Cancer
por: Liu, Ching-Wen, et al.
Publicado: (2022)

Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages
por: Hu, Li, et al.
Publicado: (2023)

Adventitial Fibroblasts in Aortic Aneurysm: Unraveling Pathogenic Contributions to Vascular Disease
por: Mackay, Cameron D. A., et al.
Publicado: (2022)

Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence
por: Saxena, Sandeep, et al.
Publicado: (2019)

Epigallocatechin gallate prevents senescence by alleviating oxidative stress and inflammation in WI-38 human embryonic fibroblasts
por: Zhang, Qiao, et al.
Publicado: (2019)

Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts
por: Wang, Ariel, et al.
Publicado: (2021)

TGF-β1/FGF-2 signaling mediates the 15-HETE-induced differentiation of adventitial fibroblasts into myofibroblasts
por: Zhang, Li, et al.
Publicado: (2016)

The Involvement of Glucose in Hydrogen Gas-Medicated Adventitious Rooting in Cucumber
por: Zhao, Zongxi, et al.
Publicado: (2021)

Adventitious Joints
por: Tyrie, C. C. Baxter
Publicado: (1894)

Bmi-1 induces radioresistance by suppressing senescence in human U87 glioma cells
por: YE, LAN, et al.
Publicado: (2014)

Effects of norepinephrine‑induced activation of rat vascular adventitial fibroblasts on proliferation and migration of BMSCs involved in vascular remodeling
por: Gao, Jun, et al.
Publicado: (2023)

PTEN inhibits replicative senescence‐induced MMP‐1 expression by regulating NOX4‐mediated ROS in human dermal fibroblasts
por: Noh, Eun‐Mi, et al.
Publicado: (2017)

DNA nanoparticles targeting FOXO4 selectively eliminate cigarette smoke-induced senescent lung fibroblasts
por: Han, Yaopin, et al.
Publicado: (2023)

Angiotensin II stimulates proliferation of adventitial fibroblasts cultured from rat aortic explants.
por: Kim, D. K., et al.
Publicado: (1999)

Captopril Alleviates Chondrocyte Senescence in DOCA-Salt Hypertensive Rats Associated with Gut Microbiome Alteration
por: Chan, Lok Chun, et al.
Publicado: (2022)

MicroRNA 128a Increases Intracellular ROS Level by Targeting Bmi-1 and Inhibits Medulloblastoma Cancer Cell Growth by Promoting Senescence
por: Venkataraman, Sujatha, et al.
Publicado: (2010)

Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages
por: Kumar, Sushil, et al.
Publicado: (2021)

Hypertension, BMI, and cardiovascular and cerebrovascular diseases
por: Qiao, Wenjing, et al.
Publicado: (2021)

Novel lncRNA LNC_000113 Drives the Activation of Pulmonary Adventitial Fibroblasts through Modulating PTEN/Akt/FoxO1 Pathway
por: Luo, Hui, et al.
Publicado: (2023)

Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change
por: Stenmark, Kurt R., et al.
Publicado: (2012)

Adventitious agents and vaccines.
por: Krause, P R
Publicado: (2001)

Resveratrol inhibits adventitial fibroblast proliferation and induces cell apoptosis through the SIRT1 pathway
por: Ling, Lin, et al.
Publicado: (2017)

Molecular mechanisms and effects of urocortin II on rat adventitial fibroblast calcification induced by calcified medium
por: Zhang, Xusheng, et al.
Publicado: (2022)

p53, ROS and senescence in the control of aging
por: Vigneron, Arnaud, et al.
Publicado: (2010)

Body Mass Index (BMI) Is Associated with Microalbuminuria in Chinese Hypertensive Patients
por: Liu, Xinyu, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hishkmr5ihshpfak7rvhkrp0pe