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Biochemistry of fluoroprolines: the prospect of making fluorine a bioelement

Due to the heterocyclic structure and distinct conformational profile, proline is unique in the repertoire of the 20 amino acids coded into proteins. Here, we summarize the biochemical work on the replacement of proline with (4R)- and (4S)-fluoroproline as well as 4,4-difluoroproline in proteins don...

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Detalles Bibliográficos
Autores principales: Kubyshkin, Vladimir, Davis, Rebecca, Budisa, Nediljko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934785/
https://www.ncbi.nlm.nih.gov/pubmed/33727970
http://dx.doi.org/10.3762/bjoc.17.40