Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling

Loss-of-function (LOF) variants in SCN1B, encoding voltage-gated sodium channel β1 subunits, are linked to human diseases with high risk of sudden death, including developmental and epileptic encephalopathy and cardiac arrhythmia. β1 Subunits modulate the cell-surface localization, gating, and kinet...

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Detalles Bibliográficos
Autores principales: Bouza, Alexandra A., Edokobi, Nnamdi, Hodges, Samantha L., Pinsky, Alexa M., Offord, James, Piao, Lin, Zhao, Yan-Ting, Lopatin, Anatoli N., Lopez-Santiago, Luis F., Isom, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934843/
https://www.ncbi.nlm.nih.gov/pubmed/33411695
http://dx.doi.org/10.1172/jci.insight.141776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934843/
https://www.ncbi.nlm.nih.gov/pubmed/33411695
http://dx.doi.org/10.1172/jci.insight.141776

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