Proximal tubular epithelial insulin receptor mediates high-fat diet–induced kidney injury

The role of insulin receptor (IR) activated by hyperinsulinemia in obesity-induced kidney injury is not well understood. We hypothesized that activation of kidney proximal tubule epithelial IR contributes to obesity-induced kidney injury. We administered normal-fat diet (NFD) or high-fat diet (HFD)...

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Detalles Bibliográficos
Autores principales: Lee, Hak Joo, Mariappan, Meenalakshmi M., Norton, Luke, Bakewell, Terry, Feliers, Denis, Oh, Sae Byeol, Donati, Andrew, Rubannelsonkumar, Cherubina S., Venkatachalam, Manjeri A., Harris, Stephen E., Rubera, Isabelle, Tauc, Michel, Ghosh Choudhury, Goutam, Kahn, C. Ronald, Sharma, Kumar, DeFronzo, Ralph A., Kasinath, Balakuntalam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934847/
https://www.ncbi.nlm.nih.gov/pubmed/33400689
http://dx.doi.org/10.1172/jci.insight.143619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934847/
https://www.ncbi.nlm.nih.gov/pubmed/33400689
http://dx.doi.org/10.1172/jci.insight.143619

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