Cargando…

Proximal tubular epithelial insulin receptor mediates high-fat diet–induced kidney injury

The role of insulin receptor (IR) activated by hyperinsulinemia in obesity-induced kidney injury is not well understood. We hypothesized that activation of kidney proximal tubule epithelial IR contributes to obesity-induced kidney injury. We administered normal-fat diet (NFD) or high-fat diet (HFD)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hak Joo, Mariappan, Meenalakshmi M., Norton, Luke, Bakewell, Terry, Feliers, Denis, Oh, Sae Byeol, Donati, Andrew, Rubannelsonkumar, Cherubina S., Venkatachalam, Manjeri A., Harris, Stephen E., Rubera, Isabelle, Tauc, Michel, Ghosh Choudhury, Goutam, Kahn, C. Ronald, Sharma, Kumar, DeFronzo, Ralph A., Kasinath, Balakuntalam S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934847/ https://www.ncbi.nlm.nih.gov/pubmed/33400689 http://dx.doi.org/10.1172/jci.insight.143619

Ejemplares similares

Erk in Kidney Diseases
por: Feliers, Denis, et al.
Publicado: (2011)

TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion
por: Dey, Nirmalya, et al.
Publicado: (2012)

Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis
por: Das, Falguni, et al.
Publicado: (2022)

TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression
por: Das, Falguni, et al.
Publicado: (2014)

Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression
por: Das, Falguni, et al.
Publicado: (2018)

Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury
por: Lee, Hak Joo, et al.
Publicado: (2021)

HIV-1 Promotes Renal Tubular Epithelial Cell Protein Synthesis: Role of mTOR Pathway
por: Rehman, Shabina, et al.
Publicado: (2012)

Hydrogen sulfide to the rescue in obstructive kidney injury
por: Kasinath, Balakuntalam S.
Publicado: (2014)

Rapamycin selectively alters serum chemistry in diabetic mice
por: Tabatabai-Mir, Hooman, et al.
Publicado: (2012)

Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes
por: Mariappan, Meenalakshmi M.
Publicado: (2012)

microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and Invasion
por: Dey, Nirmalya, et al.
Publicado: (2012)

Regulation of Glomerular Endothelial Cell Proteoglycans by Glucose
por: Ha, Tae-Sun, et al.
Publicado: (2004)

Novel Hypothesis to Explain Why SGLT2 Inhibitors Inhibit Only 30–50% of Filtered Glucose Load in Humans
por: Abdul-Ghani, Muhammad A., et al.
Publicado: (2013)

Revisiting CFTR inhibition: a comparative study of CFTR(inh)-172 and GlyH-101 inhibitors
por: Melis, N, et al.
Publicado: (2014)

Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity
por: Rubera, I, et al.
Publicado: (2013)

Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance
por: Friard, Jonas, et al.
Publicado: (2017)

Role of TASK2 Potassium Channels Regarding Volume Regulation in Primary Cultures of Mouse Proximal Tubules
por: Barriere, Herve, et al.
Publicado: (2003)

Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009
por: DeFronzo, R. A.
Publicado: (2010)

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
por: DeFronzo, Ralph A.
Publicado: (2009)

Bromocriptine: A Sympatholytic, D2-Dopamine Agonist for the Treatment of Type 2 Diabetes
por: DeFronzo, Ralph A.
Publicado: (2011)

Fatigue characteristics on dialysis and non-dialysis days in patients with chronic kidney failure on maintenance hemodialysis
por: Debnath, Subrata, et al.
Publicado: (2021)

Proximal tubule specific knockout of the Na(+)/H(+) exchanger NHE3: effects on bicarbonate absorption and ammonium excretion
por: Li, Hong C., et al.
Publicado: (2013)

LRRC8/VRAC channels exhibit a noncanonical permeability to glutathione, which modulates epithelial-to-mesenchymal transition (EMT)
por: Friard, Jonas, et al.
Publicado: (2019)

Akt Inhibition as Preconditioning Treatment to Protect Kidney Cells against Anoxia
por: Melis, Nicolas, et al.
Publicado: (2021)

Autophagy inhibition by chloroquine and hydroxychloroquine could adversely affect acute kidney injury and other organ injury in critically ill patients with COVID-19
por: Edelstein, Charles L., et al.
Publicado: (2020)

Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
por: DeFronzo, Ralph A., et al.
Publicado: (2009)

Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type
por: Miyazaki, Yoshinori, et al.
Publicado: (2009)

Is Incretin-Based Therapy Ready for the Care of Hospitalized Patients With Type 2 Diabetes?: The time has come for GLP-1 receptor agonists!
por: Schwartz, Stanley, et al.
Publicado: (2013)

A novel experimental model for human mixed acinar–ductal pancreatic cancer
por: Doiron, Bruno, et al.
Publicado: (2018)

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells
por: Norton, Luke, et al.
Publicado: (2014)

Increased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects
por: Eldor, Roy, et al.
Publicado: (2017)

Type 2 Diabetes Can Be Prevented With Early Pharmacological Intervention
por: DeFronzo, Ralph A., et al.
Publicado: (2011)

Is It Time to Change the Type 2 Diabetes Treatment Paradigm? Yes! GLP-1 RAs Should Replace Metformin in the Type 2 Diabetes Algorithm
por: Abdul-Ghani, Muhammad, et al.
Publicado: (2017)

Modifying chronic kidney disease progression with the mineralocorticoid receptor antagonist finerenone in patients with type 2 diabetes
por: DeFronzo, Ralph A., et al.
Publicado: (2022)

Altered Insulin Clearance after Gastric Bypass and Sleeve Gastrectomy in the Fasting and Prandial Conditions
por: Salehi, Marzieh, et al.
Publicado: (2022)

A Novel Role for MAP1 LC3 in Non-Autophagic Cytoplasmic Vacuolation Death of Cancer Cells
por: Kar, Rekha, et al.
Publicado: (2009)

Pathogenesis of Insulin Resistance in Skeletal Muscle
por: Abdul-Ghani, Muhammad A., et al.
Publicado: (2010)

Plasma Glucose Concentration and Prediction of Future Risk of Type 2 Diabetes
por: Abdul-Ghani, Muhammad A., et al.
Publicado: (2009)

Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment
por: Triplitt, Curtis, et al.
Publicado: (2010)

Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice
por: Doiron, Bruno, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5bg80po5h8h6ig3f072k0j74sg