An early endothelial cell–specific requirement for Glut1 is revealed in Glut1 deficiency syndrome model mice

Paucity of the glucose transporter-1 (Glut1) protein resulting from haploinsufficiency of the SLC2A1 gene arrests cerebral angiogenesis and disrupts brain function to cause Glut1 deficiency syndrome (Glut1 DS). Restoring Glut1 to Glut1 DS model mice prevents disease, but the precise cellular sites o...

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Detalles Bibliográficos
Autores principales: Tang, Maoxue, Park, Sarah H., Petri, Sabrina, Yu, Hang, Rueda, Carlos B., Abel, E. Dale, Kim, Carla Y., Hillman, Elizabeth M.C., Li, Fanghua, Lee, Yeojin, Ding, Lei, Jagadish, Smitha, Frankel, Wayne N., De Vivo, Darryl C., Monani, Umrao R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934852/
https://www.ncbi.nlm.nih.gov/pubmed/33351789
http://dx.doi.org/10.1172/jci.insight.145789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934852/
https://www.ncbi.nlm.nih.gov/pubmed/33351789
http://dx.doi.org/10.1172/jci.insight.145789

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