GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that potentiates glucose-stimulated insulin secretion. GLP-1 is classically produced by gut L cells; however, under certain circumstances α cells can express the prohormone convertase required for proglucagon processing to GLP-1, prohormone conv...

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Detalles Bibliográficos
Autores principales: Saikia, Mridusmita, Holter, Marlena M., Donahue, Leanne R., Lee, Isaac S., Zheng, Qiaonan C., Wise, Journey L., Todero, Jenna E., Phuong, Daryl J., Garibay, Darline, Coch, Reilly, Sloop, Kyle W., Garcia-Ocana, Adolfo, Danko, Charles G., Cummings, Bethany P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934853/
https://www.ncbi.nlm.nih.gov/pubmed/33554958
http://dx.doi.org/10.1172/jci.insight.141851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934853/
https://www.ncbi.nlm.nih.gov/pubmed/33554958
http://dx.doi.org/10.1172/jci.insight.141851

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