Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice

Alpha-1 antitrypsin (AAT) is a major inhibitor of serine proteases in mammals. Therefore, its deficiency leads to protease–antiprotease imbalance and a risk for developing lung emphysema. Although therapy with human plasma-purified AAT attenuates AAT deficiency–related emphysema, its impact on lung...

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Detalles Bibliográficos
Autores principales: Ostermann, Lena, Maus, Regina, Stolper, Jennifer, Schütte, Lisanne, Katsarou, Konstantina, Tumpara, Srinu, Pich, Andreas, Mueller, Christian, Janciauskiene, Sabina, Welte, Tobias, Maus, Ulrich A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934856/
https://www.ncbi.nlm.nih.gov/pubmed/33554955
http://dx.doi.org/10.1172/jci.insight.140816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934856/
https://www.ncbi.nlm.nih.gov/pubmed/33554955
http://dx.doi.org/10.1172/jci.insight.140816

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