Acetylation of muscle creatine kinase negatively impacts high-energy phosphotransfer in heart failure

A hallmark of impaired myocardial energetics in failing hearts is the downregulation of the creatine kinase (CK) system. In heart failure patients and animal models, myocardial phosphocreatine content and the flux of the CK reaction are negatively correlated with the outcome of heart failure. While...

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Detalles Bibliográficos
Autores principales: Walker, Matthew A., Chavez, Juan, Villet, Outi, Tang, Xiaoting, Keller, Andrew, Bruce, James E., Tian, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934860/
https://www.ncbi.nlm.nih.gov/pubmed/33554956
http://dx.doi.org/10.1172/jci.insight.144301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934860/
https://www.ncbi.nlm.nih.gov/pubmed/33554956
http://dx.doi.org/10.1172/jci.insight.144301

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