Syngeneic tobacco carcinogen–induced mouse lung adenocarcinoma model exhibits PD-L1 expression and high tumor mutational burden

Human lung adenocarcinoma (LUAD) in current or former smokers exhibits a high tumor mutational burden (TMB) and distinct mutational signatures. Syngeneic mouse models of clinically relevant smoking-related LUAD are lacking. We established and characterized a tobacco-associated, transplantable murine...

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Detalles Bibliográficos
Autores principales: Stabile, Laura P., Kumar, Vinod, Gaither-Davis, Autumn, Huang, Eric H., Vendetti, Frank P., Devadassan, Princey, Dacic, Sanja, Bao, Riyue, Steinman, Richard A., Burns, Timothy F., Bakkenist, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934870/
https://www.ncbi.nlm.nih.gov/pubmed/33351788
http://dx.doi.org/10.1172/jci.insight.145307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934870/
https://www.ncbi.nlm.nih.gov/pubmed/33351788
http://dx.doi.org/10.1172/jci.insight.145307

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