The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling

The G/T transversion rs35705950, located approximately 3 kb upstream of the MUC5B start site, is the cardinal risk factor for idiopathic pulmonary fibrosis (IPF). Here, we investigate the function and chromatin structure of this –3 kb region and provide evidence that it functions as a classically de...

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Detalles Bibliográficos
Autores principales: Gally, Fabienne, Sasse, Sarah K., Kurche, Jonathan S., Gruca, Margaret A., Cardwell, Jonathan H., Okamoto, Tsukasa, Chu, Hong W., Hou, Xiaomeng, Poirion, Olivier B., Buchanan, Justin, Preissl, Sebastian, Ren, Bing, Colgan, Sean P., Dowell, Robin D., Yang, Ivana V., Schwartz, David A., Gerber, Anthony N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934873/
https://www.ncbi.nlm.nih.gov/pubmed/33320836
http://dx.doi.org/10.1172/jci.insight.144294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934873/
https://www.ncbi.nlm.nih.gov/pubmed/33320836
http://dx.doi.org/10.1172/jci.insight.144294

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