Restoration of type I interferon signaling in intrahepatically primed CD8(+) T cells promotes functional differentiation

Hepatitis B virus–specific (HBV-specific) CD8(+) T cells fail to acquire effector functions after priming in the liver, but the molecular basis for the dysfunction is poorly understood. By comparing the gene expression profile of intrahepatically primed, dysfunctional HBV-specific CD8(+) T cells wit...

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Detalles Bibliográficos
Autores principales: Kawashima, Keigo, Isogawa, Masanori, Onishi, Masaya, Baudi, Ian, Saito, Satoru, Nakajima, Atsushi, Fujita, Takashi, Tanaka, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934883/
https://www.ncbi.nlm.nih.gov/pubmed/33400688
http://dx.doi.org/10.1172/jci.insight.145761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934883/
https://www.ncbi.nlm.nih.gov/pubmed/33400688
http://dx.doi.org/10.1172/jci.insight.145761

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