Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr(1160) phosphorylation

White adipose tissue (WAT) insulin action has critical anabolic function and is dysregulated in overnutrition. However, the mechanism of short-term high-fat diet–induced (HFD-induced) WAT insulin resistance (IR) is poorly understood. Based on recent evidences, we hypothesize that a short-term HFD ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Lyu, Kun, Zhang, Dongyan, Song, Joongyu, Li, Xiruo, Perry, Rachel J., Samuel, Varman T., Shulman, Gerald I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934919/
https://www.ncbi.nlm.nih.gov/pubmed/33411692
http://dx.doi.org/10.1172/jci.insight.139946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934919/
https://www.ncbi.nlm.nih.gov/pubmed/33411692
http://dx.doi.org/10.1172/jci.insight.139946

Ejemplares similares