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Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr(1160) phosphorylation

White adipose tissue (WAT) insulin action has critical anabolic function and is dysregulated in overnutrition. However, the mechanism of short-term high-fat diet–induced (HFD-induced) WAT insulin resistance (IR) is poorly understood. Based on recent evidences, we hypothesize that a short-term HFD ca...

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Detalles Bibliográficos
Autores principales:	Lyu, Kun, Zhang, Dongyan, Song, Joongyu, Li, Xiruo, Perry, Rachel J., Samuel, Varman T., Shulman, Gerald I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934919/ https://www.ncbi.nlm.nih.gov/pubmed/33411692 http://dx.doi.org/10.1172/jci.insight.139946

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