Cargando…

A STAT3 inhibitor ameliorates CNS autoimmunity by restoring Teff:Treg balance

Reestablishing an appropriate balance between T effector cells (Teff) and Tregs is essential for correcting autoimmunity. Multiple sclerosis (MS) is an immune-mediated chronic CNS disease characterized by neuroinflammation, demyelination, and neuronal degeneration, in which the Teff:Treg balance is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aqel, Saba I., Yang, Xiaozhi, Kraus, Emma E., Song, Jinhua, Farinas, Marissa F., Zhao, Erin Y., Pei, Wei, Lovett-Racke, Amy E., Racke, Michael K., Li, Chenglong, Yang, Yuhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934926/ https://www.ncbi.nlm.nih.gov/pubmed/33411696 http://dx.doi.org/10.1172/jci.insight.142376

Ejemplares similares

Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα
por: Nuro-Gyina, Patrick K, et al.
Publicado: (2016)

Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs
por: Yang, Yuhong, et al.
Publicado: (2010)

IL-3 Is a Marker of Encephalitogenic T Cells, but Not Essential for CNS Autoimmunity
por: Lee, Priscilla W., et al.
Publicado: (2018)

Neuron-Specific Vitamin D Signaling Attenuates Microglia Activation and CNS Autoimmunity
por: Lee, Priscilla W., et al.
Publicado: (2020)

PPAR Alpha Regulation of the Immune Response and Autoimmune Encephalomyelitis
por: Yang, Yuhong, et al.
Publicado: (2008)

Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer
por: Eriksson, Emma, et al.
Publicado: (2016)

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells
por: Yang, Yuhong, et al.
Publicado: (2009)

MicroRNA-21-5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo
por: Huo, Jing, et al.
Publicado: (2021)

Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis
por: Pennisi, Marzio, et al.
Publicado: (2013)

Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels
por: Jukkola, Peter, et al.
Publicado: (2017)

Characterization of teff straw from selected teff varieties from Ethiopia
por: Tessema, Belete, et al.
Publicado: (2023)

Editorial: Pain in multiple sclerosis and experimental autoimmune encephalomyelitis
por: Lovett-Racke, Amy, et al.
Publicado: (2022)

Vitamin D as a Risk Factor for Multiple Sclerosis: Immunoregulatory or Neuroprotective?
por: Gombash, Sara E., et al.
Publicado: (2022)

Following the Fate of One Insulin-Reactive CD4 T cell: Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice
por: Fousteri, Georgia, et al.
Publicado: (2012)

Treg in CNS autoimmune disease
por: Anderton, Stephen M
Publicado: (2012)

Lectures on nonlinear evolution equations: initial value problems
por: Racke, Reinhard
Publicado: (2015)

Lectures on nonlinear evolution equations: initial value problem
por: Racke, Reinhard
Publicado: (1992)

Immunopathogenesis of multiple sclerosis
por: Racke, Michael K.
Publicado: (2009)

A Review on Factors Influencing the Fermentation Process of Teff (Eragrostis teff) and Other Cereal-Based Ethiopian Injera
por: Mengesha, Yizengaw, et al.
Publicado: (2022)

Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway
por: Chen, Yuxi, et al.
Publicado: (2020)

PEG Minocycline-Liposomes Ameliorate CNS Autoimmune Disease
por: Hu, Wei, et al.
Publicado: (2009)

Evolution equations in thermoelasticity
por: Racke, Reinhard, et al.
Publicado: (2000)

TLR3 agonism re‐establishes CNS immune competence during α4‐integrin deficiency
por: Hussain, Rehana Z., et al.
Publicado: (2018)

Apolipoprotein A1 Modulates Teff/Treg Balance Through Scavenger Receptor Class B Type I-Dependent Mechanisms in Experimental Autoimmune Uveitis
por: Huang, Haixiang, et al.
Publicado: (2022)

The Effect of Teff Seed on Hematological Findings and Anthropometric Measurements
por: Demir, Eftal Geçgil, et al.
Publicado: (2022)

PPARs in Neuroinflammation
por: Racke, Michael K., et al.
Publicado: (2008)

Multiple sclerosis and COVID-19: A great opportunity for databases promoting research and collaboration
por: Racke, Michael K., et al.
Publicado: (2020)

Multiple Sclerosis Followed by Neuromyelitis Optica Spectrum Disorder: From the National Multiple Sclerosis Society Case Conference Proceedings
por: Goldschmidt, Carolyn, et al.
Publicado: (2022)

Exceptional subgenome stability and functional divergence in the allotetraploid Ethiopian cereal teff
por: VanBuren, Robert, et al.
Publicado: (2020)

Teff Type-I Sourdough to Produce Gluten-Free Muffin
por: Dingeo, Cinzia, et al.
Publicado: (2020)

Determination and Analysis of Composition, Structure, and Properties of Teff Protein Fractions
por: Quan, Zhenyang, et al.
Publicado: (2023)

A case of allergy to Silybum marianum (milk thistle) and Eragrostis tef (teff)
por: Wojas, O., et al.
Publicado: (2020)

Isolation and Characterization of Probiotic LAB from Kimchi and Spontaneously Fermented Teff (Eragrostis tef (Zucc.) Trotter) Batter: Their Effects on Phenolic Content of Teff during Fermentation
por: Gebru, Yoseph Asmelash, et al.
Publicado: (2020)

PPAR-γ: Therapeutic Potential for Multiple Sclerosis
por: Drew, Paul D., et al.
Publicado: (2008)

Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinical Vignettes
por: Racke, Michael K., et al.
Publicado: (2022)

Nutritional composition of Eragrostis teff and its association with the observed antimutagenic effects
por: Goersch, Maria Clara da Silva, et al.
Publicado: (2019)

Nutritional Values of Teff (Eragrostis tef) in Diabetic Patients: Narrative Review
por: Habte, Mezgebu Legesse, et al.
Publicado: (2022)

Treatment of Experimental Autoimmune Encephalomyelitis by Codelivery of Disease Associated Peptide and Dexamethasone in Acetalated Dextran Microparticles
por: Peine, Kevin J., et al.
Publicado: (2014)

Therapeutic targeting of STAT pathways in CNS autoimmune diseases
por: Egwuagu, Charles E., et al.
Publicado: (2013)

PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER
por: Vang, Amanda G., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_j7qcld8o55gpsetf1k71i09nch