Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity

MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The present study aimed at determining whether pharmacological chaperones (PCs) that restore folding and plasma membrane traf...

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Detalles Bibliográficos
Autores principales: René, Patricia, Lanfray, Damien, Richard, Denis, Bouvier, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934941/
https://www.ncbi.nlm.nih.gov/pubmed/33434184
http://dx.doi.org/10.1172/jci.insight.132778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934941/
https://www.ncbi.nlm.nih.gov/pubmed/33434184
http://dx.doi.org/10.1172/jci.insight.132778

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