Cargando…
Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity
MC4R mutations represent the largest monogenic cause of obesity, resulting mainly from receptor misfolding and intracellular retention by the cellular quality control system. The present study aimed at determining whether pharmacological chaperones (PCs) that restore folding and plasma membrane traf...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Clinical Investigation
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934941/ https://www.ncbi.nlm.nih.gov/pubmed/33434184 http://dx.doi.org/10.1172/jci.insight.132778 |