Systematic analysis of factors that improve homologous direct repair (HDR) efficiency in CRISPR/Cas9 technique

The CRISPR/Cas9 bacterial system has proven to be an powerful tool for genetic manipulation in several organisms, but the efficiency of sequence replacement by homologous direct repair (HDR) is substantially lower than random indel creation. Many studies focused on improving HDR efficiency using dou...

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Detalles Bibliográficos
Autores principales: Di Stazio, Mariateresa, Foschi, Nicola, Athanasakis, Emmanouil, Gasparini, Paolo, d’Adamo, Adamo Pio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935300/
https://www.ncbi.nlm.nih.gov/pubmed/33667229
http://dx.doi.org/10.1371/journal.pone.0247603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935300/
https://www.ncbi.nlm.nih.gov/pubmed/33667229
http://dx.doi.org/10.1371/journal.pone.0247603

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