RNF39 mediates K48-linked ubiquitination of DDX3X and inhibits RLR-dependent antiviral immunity

Retinoic acid–inducible gene-I (RIG-I)–like receptors (RLRs) are major cytosolic RNA sensors and play crucial roles in initiating antiviral innate immunity. Furthermore, RLRs have been implicated in multiple autoimmune disorders. Thus, RLR activation should be tightly controlled to avoid detrimental...

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Detalles Bibliográficos
Autores principales: Wang, Wenwen, Jia, Mutian, Zhao, Chunyuan, Yu, Zhongxia, Song, Hui, Qin, Ying, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935364/
https://www.ncbi.nlm.nih.gov/pubmed/33674311
http://dx.doi.org/10.1126/sciadv.abe5877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935364/
https://www.ncbi.nlm.nih.gov/pubmed/33674311
http://dx.doi.org/10.1126/sciadv.abe5877

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