Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA

Self-amplifying RNA (saRNA) is a cutting-edge platform for both nucleic acid vaccines and therapeutics. saRNA is self-adjuvanting, as it activates types I and III interferon (IFN), which enhances the immunogenicity of RNA vaccines but can also lead to inhibition of translation. In this study, we scr...

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Detalles Bibliográficos
Autores principales: Blakney, Anna K., McKay, Paul F., Bouton, Clément R., Hu, Kai, Samnuan, Karnyart, Shattock, Robin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935664/
https://www.ncbi.nlm.nih.gov/pubmed/33352107
http://dx.doi.org/10.1016/j.ymthe.2020.11.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935664/
https://www.ncbi.nlm.nih.gov/pubmed/33352107
http://dx.doi.org/10.1016/j.ymthe.2020.11.011

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