High-throughput fetal fraction amplification increases analytical performance of noninvasive prenatal screening

PURPOSE: The percentage of a maternal cell-free DNA (cfDNA) sample that is fetal-derived (the fetal fraction; FF) is a key driver of the sensitivity and specificity of noninvasive prenatal screening (NIPS). On certain NIPS platforms, >20% of women with high body mass index (and >5% overall) re...

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Detalles Bibliográficos
Autores principales: Welker, Noah C., Lee, Albert K., Kjolby, Rachel A. S., Wan, Helen Y., Theilmann, Mark R., Jeon, Diana, Goldberg, James D., Haas, Kevin R., Muzzey, Dale, Chu, Clement S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935715/
https://www.ncbi.nlm.nih.gov/pubmed/33190143
http://dx.doi.org/10.1038/s41436-020-01009-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935715/
https://www.ncbi.nlm.nih.gov/pubmed/33190143
http://dx.doi.org/10.1038/s41436-020-01009-5

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