Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling

Previous work has suggested androgen receptor (AR) signaling mediates prostate cancer progression in part through the modulation of autophagy. However, clinical trials testing autophagy inhibition using chloroquine derivatives in men with castration-resistant prostate cancer (CRPC) have yet to yield...

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Detalles Bibliográficos
Autores principales: Lin, Chenchu, Blessing, Alicia M., Pulliam, Thomas L., Shi, Yan, Wilkenfeld, Sandi R., Han, Jenny J., Murray, Mollianne M., Pham, Alexander H., Duong, Kevin, Brun, Sonja N., Shaw, Reuben J., Ittmann, Michael M., Frigo, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935762/
https://www.ncbi.nlm.nih.gov/pubmed/33531625
http://dx.doi.org/10.1038/s41388-021-01658-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935762/
https://www.ncbi.nlm.nih.gov/pubmed/33531625
http://dx.doi.org/10.1038/s41388-021-01658-z

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