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Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma

We have previously identified receptor tyrosine kinase‐like orphan receptor 1 (ROR1) as a direct transcriptional target of TTF‐1/NKX2‐1, a lineage‐survival oncogene in lung adenocarcinoma. ROR1 sustains prosurvival signaling from multiple receptor tyrosine kinases including epidermal growth factor r...

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Detalles Bibliográficos
Autores principales: Khaledian, Behnoush, Taguchi, Ayumu, Shin‐ya, Kazuo, Kondo‐Ida, Lisa, Kagaya, Noritaka, Suzuki, Motoshi, Kajino, Taisuke, Yamaguchi, Tomoya, Shimada, Yukako, Takahashi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935804/
https://www.ncbi.nlm.nih.gov/pubmed/33370472
http://dx.doi.org/10.1111/cas.14786