Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data

BACKGROUND AND OBJECTIVES: The pharmacokinetics of polyethylene glycol-conjugated asparaginase (PEG-ASNase) are characterized by an increase in elimination over time, a marked increase in ASNase activity levels from induction to reinduction, and high inter- and intraindividual variability. A populat...

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Detalles Bibliográficos
Autores principales: Würthwein, Gudrun, Lanvers-Kaminsky, Claudia, Siebel, Christian, Gerß, Joachim, Möricke, Anja, Zimmermann, Martin, Stary, Jan, Smisek, Petr, Schrappe, Martin, Rizzari, Carmelo, Zucchetti, Massimo, Hempel, Georg, Wicha, Sebastian G., Boos, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935823/
https://www.ncbi.nlm.nih.gov/pubmed/33595793
http://dx.doi.org/10.1007/s13318-021-00670-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935823/
https://www.ncbi.nlm.nih.gov/pubmed/33595793
http://dx.doi.org/10.1007/s13318-021-00670-8

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