KRAS drives immune evasion in a genetic model of pancreatic cancer

Immune evasion is a hallmark of KRAS-driven cancers, but the underlying causes remain unresolved. Here, we use a mouse model of pancreatic ductal adenocarcinoma to inactivate KRAS by CRISPR-mediated genome editing. We demonstrate that at an advanced tumor stage, dependence on KRAS for tumor growth i...

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Detalles Bibliográficos
Autores principales: Ischenko, Irene, D’Amico, Stephen, Rao, Manisha, Li, Jinyu, Hayman, Michael J., Powers, Scott, Petrenko, Oleksi, Reich, Nancy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935870/
https://www.ncbi.nlm.nih.gov/pubmed/33674596
http://dx.doi.org/10.1038/s41467-021-21736-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935870/
https://www.ncbi.nlm.nih.gov/pubmed/33674596
http://dx.doi.org/10.1038/s41467-021-21736-w

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