Cargando…

KRAS drives immune evasion in a genetic model of pancreatic cancer

Immune evasion is a hallmark of KRAS-driven cancers, but the underlying causes remain unresolved. Here, we use a mouse model of pancreatic ductal adenocarcinoma to inactivate KRAS by CRISPR-mediated genome editing. We demonstrate that at an advanced tumor stage, dependence on KRAS for tumor growth i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ischenko, Irene, D’Amico, Stephen, Rao, Manisha, Li, Jinyu, Hayman, Michael J., Powers, Scott, Petrenko, Oleksi, Reich, Nancy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935870/ https://www.ncbi.nlm.nih.gov/pubmed/33674596 http://dx.doi.org/10.1038/s41467-021-21736-w

Ejemplares similares

A MEK/PI3K/HDAC inhibitor combination therapy for KRAS mutant pancreatic cancer cells
por: Ischenko, Irene, et al.
Publicado: (2015)

STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer
por: D’Amico, Stephen, et al.
Publicado: (2023)

KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents
por: Ischenko, Irene, et al.
Publicado: (2017)

STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis
por: D'Amico, Stephen, et al.
Publicado: (2018)

IL-6 promotes MYC-induced B cell lymphomagenesis independent of STAT3
por: Petrenko, Oleksi, et al.
Publicado: (2021)

Direct reprogramming en route to neoplastic transformation
por: Nemajerova, Alice, et al.
Publicado: (2013)

Effectors and potential targets selectively upregulated in human KRAS-mutant lung adenocarcinomas
por: Li, Jinyu, et al.
Publicado: (2016)

Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47
por: Hu, Huanhuan, et al.
Publicado: (2023)

MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models
por: Fingerle-Rowson, Günter, et al.
Publicado: (2007)

Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T‐Cells to Activation‐Induced Cell Death in Colorectal Cancer
por: Liu, Huashan, et al.
Publicado: (2023)

Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer
por: Lidström, Tommy, et al.
Publicado: (2023)

Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells
por: Suzuki, Tatsunori, et al.
Publicado: (2021)

Cancer immune evasion through KRAS and PD-L1 and potential therapeutic interventions
por: Watterson, Alex, et al.
Publicado: (2023)

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth
por: Nagdas, Sarbajeet, et al.
Publicado: (2019)

Targeted Deletion of p73 in Mice Reveals Its Role in T Cell Development and Lymphomagenesis
por: Nemajerova, Alice, et al.
Publicado: (2009)

KRAS, MYC, and ARF6: inseparable relationships cooperatively promote cancer malignancy and immune evasion
por: Sabe, Hisataka
Publicado: (2023)

Targeting KRAS in Pancreatic Cancer
por: Cowzer, Darren, et al.
Publicado: (2022)

KRAS RENAISSANCE(S) in Tumor Infiltrating B Cells in Pancreatic Cancer
por: Meng, Qingda, et al.
Publicado: (2018)

Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome
por: Lemstrova, Radmila, et al.
Publicado: (2017)

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
por: Hashimoto, Shigeru, et al.
Publicado: (2019)

The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells
por: Feres, K.J., et al.
Publicado: (2008)

Preliminary design of the CLIC drive beam transfer line
por: D’Amico, T E, et al.
Publicado: (1999)

Preliminary design of the CLIC drive-beam transfer line
por: D'Amico, T E, et al.
Publicado: (1999)

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer
por: Boutin, Adam T., et al.
Publicado: (2017)

Oncogenic KRAS signalling in pancreatic cancer
por: Eser, S, et al.
Publicado: (2014)

Immune Evasion in Pancreatic Cancer: From Mechanisms to Therapy
por: Martinez-Bosch, Neus, et al.
Publicado: (2018)

In vivo reprogramming drives Kras-induced cancer development
por: Shibata, Hirofumi, et al.
Publicado: (2018)

Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion
por: Deruy, E, et al.
Publicado: (2014)

Ovarian cancer mutational processes drive site-specific immune evasion
por: Vázquez-García, Ignacio, et al.
Publicado: (2022)

Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells
por: El-Kenawi, Asmaa, et al.
Publicado: (2023)

Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer
por: Sivaram, Nithya, et al.
Publicado: (2019)

KRAS mutant allele-specific expression knockdown in pancreatic cancer model with systemically delivered bi-shRNA KRAS lipoplex
por: Rao, Donald D., et al.
Publicado: (2018)

KRAS above and beyond – EGFR in pancreatic cancer
por: Siveke, Jens T., et al.
Publicado: (2012)

Beyond Kras: MYC Rules in Pancreatic Cancer
por: Korc, Murray
Publicado: (2018)

Zebrafish model of KRAS-initiated pancreatic cancer
por: Park, Joon Tae, et al.
Publicado: (2018)

Neural and Genetic Basis of Evasion, Approach and Predation
por: Park, Seahyung, et al.
Publicado: (2022)

Targeting pancreatic cancer immune evasion by inhibiting histone deacetylases
por: Sim, Wynne, et al.
Publicado: (2022)

Targeting KRAS in pancreatic adenocarcinoma: Progress in demystifying the holy grail
por: Elhariri, Ahmed, et al.
Publicado: (2023)

KRAS-Dependency in Pancreatic Ductal Adenocarcinoma: Mechanisms of Escaping in Resistance to KRAS Inhibitors and Perspectives of Therapy
por: Gurreri, Enrico, et al.
Publicado: (2023)

Microenvironmental Features Driving Immune Evasion in Myelodysplastic Syndromes and Acute Myeloid Leukemia
por: Barakos, Georgios Petros, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ri5uu13np7u0ekvgi1g5krsb2s